Angels of the Universe portrays the life of Paul, who suffers from schizophrenia, and the way people react to his illness. At first we see him with his family, childhood friends and the girl (Halldóra Geirhardsdóttir) that he loves, and then we follow him into the psychiatric hospital. There we meet his colourful companions Óli Beatle (Baltasar Kormákur), who believes he has written all the Beatles songs and sent them to the group as telepathic messages; the sophisticated and erudite Viktor (Björn Jörundur), who sometimes suddenly turns into Hitler; and Peter (Hilmir Snær Gudnason), Paul's room-mate, who has freaked out on acid and is under the impression he wrote a doctorate about Schiller at a Chinese university.